Year Publication
2021 Clifford, Sedgeman, Williams, Morand, Cheng, Jarrett, Chan, Brearely-Sholto, Wahlström, Ashby, Barshop, Wolhschlegel, Calkin, Liu, Thorell, Meikle, Drew, Mack, Marschall, Tarling, Edwards, de Aguiar Vallim. (2021). FXR activation protects against NAFLD via bile acid-dependent reductions in lipid absorption. Cell Metab, 33(8), pp1671-1684.
2021 Zhuang, Calkin, Lau, Kiriazis, Donner, Liu, Bond, Moody, Gould, Colgan, Carmona, Inouye, de Aguiar Vallim, Tarling, Quaife-Ryan, Hudson, Porello, Gregorovic, Gao, Du, McMullen, Drew. (2021). Loss of the long non-coding RNA OIP5-AS1 exacerbates heart failure in a sex-specific manner. iScience, 24(6), pp102537.
2021 de Aguiar Vallim, Tarling. (2021). mInd the gAP. Circ Res, 128(11), pp1660-1662.
2021 Anastasia, Ilacqua, Raimondi, Lemieux, Ghandehari-Alavijeh, Faure, Mekhedov, Williams, Caicci, Valle, Giacomello, Quiroga, Lehner, Miksis, Toth, de Aguiar Vallim, Koonin, Scorrano, Pellegrini. (2021). Mitochondria-rough-ER contacts in the liver regulate systemic lipid homeostasis. Cell Rep, 34(11), pp108873.
2021 von Sheidt, Zhao, de Aguiar Vallim, Che, Wierer, Seldin, Franzén, Kurt, Pang, Bongiovanni, Yamamoto, Edwards, Ruusalepp, Kovacic, Mann, Björkegren, Lusis, Yang, Schunkert. (2021). Transcription Factor MAFF (MAF Basic Leucine Zipper Transcription Factor F) Regulates an Atherosclerosis Relevant Network Connecting Inflammation and Cholesterol Metabolism. Circulation, 143(18), pp1809-1823.
2021 Bond, King, Henstridge, Tran, Moody, Yang, Liu, Mellett, Nath Inouye, Tarling, de Aguiar Vallim, Meikle, Calkin, Drew. (2021). Deletion of Trim28 in committed adipocytes promotes obesity but preserves glucose tolerance. Nat Commun, 12(74).
2020 Clifford, Jarrett, Cheng, Cheng, Seldin, Morand, Lee, Baldan, de Aguiar Vallim, Tarling. (2020). GOLIATH regulates LDLR availbility and plasma LDL cholesterol levels. bioRxiv.
2020 Zhou, Chi, Lee, Hsieh, Mkrtchyan, Feng, He, York, Bui, Kronenberger, Ferrari, Xiao, Daly, Tarling, Damoiseaux, Scumpia, Smale, Williams, Tontonoz, Bensinger. (2020). Interferon-mediated reprogramming of membrane cholesterol to evade bacterial toxins. Nat Immunol, 21(7), pp746-755.
2020 Pradas-Juni, Hansmeier, Link, Schmidt, Larsen, Klemm, Meola, Topei, Loureiro, Dhaoudai, Kiefer, Schwarzer, Khani, Oliverio, Awazawa, Frommolt, Heeren, Scheja, Heine, Dietrich, Buning, Yang, Cao, Jesus, Kulkarni, Zevnik, Troder, Knippschild, Edwards, Lee, Yamamoto, Ulitsky, Fernandez-Rebollo, Vallim, Kornfeld (2020). A MAFG-lncRNA axis links systemic nutrient abundance to hepatic glucose metabolism. Nat Commun, 11(1), pp644.
2020 Cheng, Cheng, Clifford, Wu, Hedin, Maegdefessel, Pamir, Sallam, Tarling, de Aguiar Vallim. (2020). MicroRNA-144 Silencing Protects Against Atherosclerosis in Male, but Not Female Mice. Arterioscler Thromb Vasc Biol, 40(2), pp412-420.
2019 Parker, Calkin, Seldin, Keating, Tarling, Yang, Moody, Liu, Zerenturk, Needham, Miller, Clifford, Morand, Watt, Meex, Peng, Lee, Jayawardana, Pan, Mellett, Weir, Lazarus, Lusis, Miekle, James, Aguiar Vallim, Drew. (2019). An integrative systems genetics analysis of mammalian lipid metabolism. Nature, 567(7747), pp187-193.
2019 Pamir, Pan, Plubell, Hutchins, Tang, Wimberger, Irwin, Aguiar Vallim, Heinecke, Lusis (2019). Genetic control of the mouse HDL proteome defines HDL traits, function, and heterogeneity. J Lipid Res, 60(3), pp. 594.
2018 Sullivan, Mullen, Schmid, Flores, Momcilovic, Sharpley, Jelinek, Whiteley, Maxwell, Wilde, Banerjee, Coller, Shackelford, Braas, Ayer, Aguiar Vallim, Lowry, Christofk (2018). Extracelular Matrix Remodeling Regulates Glucose Metabolism through TXNIP Destabilization. Cell, 175(1), pp.117.
2018 McCarthy, Lee, Bridges, Sallese, Suzuki, Woods, Bartholmai, Wang, Chalk, Carey, Arumugam, Shima, Tarling, Trapnell (2018). Statin as a novel pharmacotherapy of pulmonary alveolar proteinosis. Nat Commun, 9(1), pp. 3127.
2018 Tumurkhuu, Dagvadorj, Porritt, Crother, Shimada, Tarling, Erbay, Arditi, Chen (2018). Chlamydia pneumoniae Hijacks a Host Autoregulatory IL-1ß Loop to Drive Foam Cell Formation and Accelerate Atherosclerosis. Cell Metab, Jun 18 pii: S1550-4131(18)30380-2.
2018 Lee, Ong, Vergnes, Aguiar Vallim, Nolan, Cantor, Walters, Reue (2018). Diet1, bile acid diarrhea, and FGF15/19: mouse model and human genetic variants. J Lipid Res, 59(3), pp.429.
2017 Mack, Mosquerio, Archer, Jones, Sunshine, Faas, Briot, Aragon, Su, Romay, McDonald, Kuo, Lizama, Lane, Zovein, Fang, Tarling, Aguiar Vallim, Navab, Fogelman, Bouchard, Iruela-Arispe (2017). NOTCH1 is a mechanosensor in adult arteries. Nat Commun, 8(1), pp.1620.
2017 Zhang, Rajbhandari, Priest, Sandhu, Wu, Temel, Castrillo, Aguiar Vallim, Sallam, Tontonoz (2017). Inhibition of cholesterol biosynthesis through RNF145-dependent ubiquitination of SCAP.
2017 Aguiar Vallim, Lee, Merriott, Goulbourne, Cheng, Cheng, Gonen, Allen, Palladino, Ford, Wang, Baldán, Tarling (2017). ABCG1 regulates pulmonary surfactant metabolism in mice and men. J Lipid Res, 58(5), pp. 941-954. (bib)
2017 Rong, Wang, Palladino, Aguiar Vallim, Ford, Tontonoz (2017). ER phospholipid composition modulates lipogenesis during feeding and in obesity. J Clin Invest, 127(10), pp. 3640-3651. (bib)
2017 Tarling, Clifford, Cheng, Morand, Cheng, Lester, Sallam, Turner, Aguiar Vallim (2017). RNA-binding protein ZFP36L1 maintains posttranscriptional regulation of bile acid metabolism. J Clin Invest, 127(10), pp. 3741-3754. (bib)
2016 Ribas, Drew, Zhou, Phun, Kalajian, Soleymani, Daraei, Widjaja, Wanagat, Aguiar Vallim, Fluitt, Bensinger, Le, Radu, Whitelegge, Beaven, Tontonoz, Lusis, Parks, Vergnes, Reue, Singh, Bopassa, Toro, Stefani, Watt, Schenk, Akerstrom, Kelly, Pedersen, Hewitt, Korach, Hevener (2016). Skeletal muscle action of estrogen receptor α is critical for the maintenance of mitochondrial function and metabolic homeostasis in females. Sci Transl Med, 8(334), pp. 334ra54. (bib)
2016 Zhang, Aguiar Vallim, Martel, Early Career Committee (2016). Translational and Therapeutic Approaches to the Understanding and Treatment of Dyslipidemia. Arterioscler Thromb Vasc Biol, 36(7), pp. e56-61. (bib)
2016 Tarling, Edwards (2016). Intracellular Localization of Endogenous Mouse ABCG1 Is Mimicked by Both ABCG1-L550 and ABCG1-P550-Brief Report. Arterioscler Thromb Vasc Biol, 36(7), pp. 1323-7. (bib)
2016 Tarling, Ryan, Austin, Kugler, Salter, Langley-Evans (2016). Maternal high-fat feeding in pregnancy programs atherosclerotic lesion size in the ApoE*3 Leiden mouse. J Dev Orig Health Dis, pp. 1-8. (bib)
2015 York, Williams, Argus, Zhou, Brar, Vergnes, Gray, Zhen, Wu, Yamada, Cunningham, Tarling, Wilks, Casero, Gray, Yu, Wang, Brooks, Sun, Kitchen, Wu, Reue, Stetson, Bensinger (2015). Limiting Cholesterol Biosynthetic Flux Spontaneously Engages Type I IFN Signaling. Cell, 163(7), pp. 1716-29. (bib)
2015 Wei, Tarling, McMillen, Tang, LeBoeuf (2015). ABCG1 regulates mouse adipose tissue macrophage cholesterol levels and ratio of M1 to M2 cells in obesity and caloric restriction. J Lipid Res, 56(12), pp. 2337-47. (bib)
2015 Ito, Hong, Rong, Zhu, Tarling, Hedde, Gratton, Parks, Tontonoz (2015). LXRs link metabolism to inflammation through Abca1-dependent regulation of membrane composition and TLR signaling. Elife, 4, pp. e08009. (bib)
2015 Tarling, Ahn, Aguiar Vallim (2015). The nuclear receptor FXR uncouples the actions of miR-33 from SREBP-2. Arterioscler Thromb Vasc Biol, 35(4), pp. 787-95. (bib)
2015 Aguiar Vallim, Tarling, Ahn, Hagey, Romanoski, Lee, Graham, Motohashi, Yamamoto, Edwards (2015). MAFG is a transcriptional repressor of bile acid synthesis and metabolism. Cell Metab, 21(2), pp. 298-310. (bib)
2014 Baldan, Gonen, Choung, Que, Marquart, Hernandez, Bjorkhem, Ford, Witztum, Tarling (2014). ABCG1 is required for pulmonary B-1 B cell and natural antibody homeostasis. J Immunol, 193(11), pp. 5637-48. (bib)
2013 Bennett, Aguiar Vallim, Wang, Shih, Meng, Gregory, Allayee, Lee, Graham, Crooke, Edwards, Hazen, Lusis (2013). Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation. Cell Metab, 17(1), pp. 49-60. (bib)
2013 Rong, Albert, Hong, Duerr, Chamberlain, Tarling, Ito, Gao, Wang, Edwards, Jung, Ford, Tontonoz (2013). LXRs regulate ER stress and inflammation through dynamic modulation of membrane phospholipid composition. Cell Metab, 18(5), pp. 685-97. (bib)
2013 Aguiar Vallim, Tarling, Kim, Civelek, Baldán, Esau, Edwards (2013). MicroRNA-144 regulates hepatic ATP binding cassette transporter A1 and plasma high-density lipoprotein after activation of the nuclear receptor farnesoid X receptor. Circ Res, 112(12), pp. 1602-12. (bib)
2012 Martin, Lau, Singh, Vergnes, Tarling, Mehrabian, Mungrue, Xiao, Shih, Castellani, Ping, Reue, Stefani, Drake, Bostrom, Lusis (2012). ABCC6 localizes to the mitochondria-associated membrane. Circ Res, 111(5), pp. 516-20. (bib)
2011 Tarling, Edwards (2011). ATP binding cassette transporter G1 (ABCG1) is an intracellular sterol transporter. Proc Natl Acad Sci U S A, 108(49), pp. 19719-24. (bib)
2010 Lee, Aguiar Vallim, Chong, Zhang, Liu, Jones, Osborne, Edwards (2010). Activation of the farnesoid X receptor provides protection against acetaminophen-induced hepatic toxicity. Mol Endocrinol, 24(8), pp. 1626-36. (bib)
2010 Jiang, Lu, Tarling, Kim, Man, Crumrine, Edwards, Elias, Feingold (2010). Regulation of ABCG1 expression in human keratinocytes and murine epidermis. J Lipid Res, 51(11), pp. 3185-95. (bib)
2010 Tarling, Bojanic, Tangirala, Wang, Lovgren-Sandblom, Lusis, Bjorkhem, Edwards (2010). Impaired development of atherosclerosis in Abcg1-/- Apoe-/- mice: identification of specific oxysterols that both accumulate in Abcg1-/- Apoe-/- tissues and induce apoptosis. Arterioscler Thromb Vasc Biol, 30(6), pp. 1174-80. (bib)